Form: EFFECT

Notice of Effectiveness

December 9, 2025

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

Notice of Effectiveness

Effectiveness Date: December 9, 2025 9:00 A.M.
Form: S-3
CIK: 0001682639
Company Name: HYPERION DEFI, INC.
File Number: 333-291570